ABSTRACT
The aim of this study was to analyze the clinical and histopathologic distribution of various types of non-Hodgkin's lymphoma [NHL] at King Abdulaziz University Hospital-Jeddah, using the World Health Organization classification [WHO] of lymphoid neoplasms and to compare our results with those reported in the literature. A hundred and nine patients with malignant NHL diagnosed over a 10-year period from January 1994 through 2004 were retrospectively studied clinically and histopathologically. They were classified using the WHO classification, and recorded in a structured form. Of the 109 patients with NHL, 42 [47.2%] were Saudi and 67 [75.3%] were Non-Saudi, with male to female ratio of 1.72:1. The mean age of the patients was 48 years, age range [12-93 years]. Immunologically, the percentage of NHL with B-cell and T-cell phenotype were 88 [80.7%] and 21 [19.3%] respectively. Diffuse large B-cell lymphoma was the most frequent histopathological diagnosis 50 [45.9%] followed by follicular lymphoma 11 [10.1%] and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma was the third most common histopathological subtype of non-Hodgkin's lymphoma 8 [7.3%]. Lymphoblastic T-cell was the predominant subtype among the T-cell non-Hodgkin's lymphoma 10 [9.2%]. The proportion of primary extranodal NHL was 20[18.3%] with the gastrointestinal tract being the commonest site in 12 of the cases. Prevalence of advanced clinical stages of the disease 58 [53.2%] were recognized. B symptoms were reported from 68[62.4%] of nodal, 11[10.1%] of extranodal NHL patients. The distribution of various types of Non-Hodgkin's lymphoma showed clinical and histopathological similarities and differences when compared using the WHO classifications with other Non-Hodgkin's lymphoma series from the region, Asian countries or the West. The age group [40-60] years seen commonly with nodal NHL while [50-80] years [older age group] present with extranodal NHL. Diffuse large B cell lymphoma represents the most common histologic subtype followed by follicular lymphoma. In contrast, T-lymphoblastic lymphoma was relatively more frequent compared with that of Western populations. Extranodal marginal zone B-cell lymphoma [MALT type] of the gastrointestinal tract accounted for majority of the primary extranodal lymphoma
Subject(s)
World Health Organization , Lymphoma, Non-Hodgkin/epidemiology , Neoplasm StagingABSTRACT
Objectives: To determine the indications and diagnosis encountered In bone marrow examihation from 1998-2004 in a university set-up and referral hospital in Jeddah, Saudi Arabia and to compare our results to those reported in the local literatures
Methods: The bone marrow records from the hematology-pathology section of King Abdul-Aziz University Hospital were reviewed. The data collected include age, sex, main indication for performing bone marrow examination and primary bone marrow diagnosis
Results: There were a total of 1023 bone marrow specimens. 645 [63%] were tram adults and 378 [37%] were from children. The MP ratio was 1.7:1. The three most common indications were suspected leukemia and postchemotherapy evaluation of bone marrow 20.9%, suspected myeloproliferative disorders 14.2% and pancytopenia 14%. The three most common specific diagnoses were acme leukemia 16.5%, aplastic anemia which includes aplasia secondary to chemotherapy for leukemia and lymphoma 14.3%. 9nd chronic myeloid leukemia 8%
Conclusion: This study confirms that bone marrow examination is a very important investigation for establishing the diagnosis in haematological diseases. Especially hematological neoplasms. The most common indication for this procedure in our hospital was to confirm and manage acute leukemia followed by myelo proliferative disorders. The most specific diagnosis made is acute leukemia
ABSTRACT
The aim of this work was to study the efficiency of tranexamic acid in reducing or preventing alveolitis after surgical removal of impacted mandibular third molar. Patients were divided into two groups. The first group received tranexamic acid. The second group received oral ampicillin. The results showed the importance of the anti fibrinolytic drugs in reducing the frequency of alveolitis. Also, the role of infection as etiologic factor of alveolitis was shown